38 products were found matching "K01542"!

A potassium-competitive acid blocker, increases TEER and occludin and Muc-1 levels at 20 µg/ml in a Caco-2 cell model of DSS-induced UC, reduces ileal levels of TNF-alpha, IL-6, and IL-1beta in a mouse model of IDM-induced small intestinal injury at 20 mg/kg. SMILES:...

Omeprazole is an inhibitor of gastric H+/K+ ATPase (IC50 = 1.1 µM for the pig ATPase). It is a racemic mixture of esomeprazole (Cay-17303) and (R)-omeprazole (Cay-18874). Omeprazole (100 µM) decreases zymosan-induced oxygen free radical production in isolated human neutrophils. It is active against 17 strains of H....

Pantoprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles with an IC50 value of 6.8 µM. It reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg) and inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat...

(R)-Omeprazole is an inhibitor of the gastric H+/K+ ATPase and an enantiomer of esomeprazole (Cay-17303). It inhibits acid secretion induced by histamine (Cay-33828) in isolated rabbit gastric glands (IC50 = 781 µM) to a lesser extent than esomeprazole. (R)-Omeprazole (30 mg/kg) inhibits histamine-induced stomach...

Omeprazole-d3 is intended for use as an internal standard for the quantification of omeprazole (Cay-14880) by GC- or LC-MS. Omeprazole is an inhibitor of gastric H+/K+ ATPase (IC50 = 1.1 µM for the pig ATPase). It is a racemic mixture of esomeprazole (Cay-17303) and (R)-omeprazole (Cay-18874). Omeprazole (100 µM)...

Vonoprazan is a selective, reversible, and potassium-competitive proton pump inhibitor that inhibits gastric H+/K+ ATPase (IC50 = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 µM. It maintains its inhibitory effect in both weakly acidic (pH 6.5) and neutral (pH 7.5)...

Rabeprazole-d4 is intended for use as an internal standard for the quantification of rabeprazole (Cay-14939) by GC- or LC-MS. Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than...

A proton pump/ATP-ase inhibitor.

Lansoprazole (Cay-13627) is a proton pump inhibitor that irreversibly inactivates the H+/K+-stimulated ATPase pumps in parietal cells, inhibiting gastric acid secretion and increasing intragastric pH. It is a 1:1 racemic mixture of (R)-lansoprazole and (S)-lansoprazole, both of which are pharmacologically active....

PF-3716556 is a potent and selective hydrogen-potassium pump (H+/K+-ATPase) inhibitor in a new class of acid suppressants, the potassium-competitive acid blockers or acid pump antagonists. PF-3716556 inhibited H+/K+-ATPase activity in porcine membrane vesicles, as well as canine and human recombinant cells under...

Lansoprazole sulfone is a phase I metabolite of lansoprazole (Cay-13627, Cay-21967, Cay-18235). Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH. Lansoprazole is metabolized...

Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole (Cay-14880), lansoprazole (Cay-13627), and pantoprazole (Cay-21345). Rabeprazole...