74 products were found matching "K01265"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse METAP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse METAP2....

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human METAP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human METAP2....

Fumagillol is a sesquiterpenoid that has been found in P. jensenii and has diverse biological activities. It is an inhibitor of methionyl aminopeptidase 2 (METAP2, IC50 = 230 nM for the human enzyme). Fumagillol is active against the parasite G. lamblia (IC50 = 3.4 µM). It reduces the proliferation of isolated calf...

TNP-470 is a synthetic analog of fumagillin (Cay-11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2, IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and...

Protein function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. [The...

Protein function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is...

Fumagillin is a fungal metabolite that has been found in A. fumigatus and has diverse biological activities. It inhibits methionyl aminopeptidase 2 (METAP2, IC50 = 10 nM). Fumagillin (10 ng/ml) inhibits tube formation in a rat blood vessel organ culture assay. It inhibits E. cuniculi replication in isolated rabbit...

Antibiotic produced by Aspergillus fumigatus. It is an antiprotozoal. Commonly used to control nosema apis in honey bees. It was found to have antineoplastic activity. It is an inhibitor of angiogenesis.

The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression...

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs, EC 3.4.11.18) (Serero et...

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs, EC 3.4.11.18) (Serero et...