93 products were found matching "K01251"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. AHCY antibody detects Adenosylhomocysteinase, an essential cytoplasmic enzyme encoded by the AHCY gene located on chromosome 20q11.22. AHCY catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and homocysteine, a...

In mammalian cells, S-adenosine homocysteine hydrolase (SAHH) is the only hydrolase involved in the hydrolysis of S-adenosine homocysteine (SAH) to homocysteine (Hcy). Excessive SAHH activity can hydrolyze SAH to generate excessive Hcy, thereby causing geriatric diseases such as Alzheimer's disease,...

Adenosine dialdehyde is an irreversible inhibitor of S-adenosylhomocysteine (SAH, Cay-13603, Cay-9000372) hydrolase (IC50 = 40 nM), blocking the conversion of SAH to homocysteine and adenosine (Cay-21232). This reduces the amount of homocysteine that can be converted to methionine and, subsequently,...

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (-)-Neplanocin A...

3-Deazaadenosine (3-DZA) is an inhibitor of S-adenosylhomocysteine hydrolase (Ki = 3.9 µM). It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-kappaB signaling. 3-DZA also has antiviral and antibacterial...

D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase (SAAH, IC50 = 7 nM). It inhibits growth of C. parvum parasites (MIC50 = 3 µM) without exhibiting cytotoxicity in HCT-8 cells (CC50 = >1 mM). Dietary administration of D-eritadenine (50 mg/kg) increases liver...

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-adenosylhomocysteine (SAH) to...

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine...

Coniferyl alcohol is a monolignol that has been found in pine sap. It is a precursor in the biosynthesis of lignin and has been used in the synthesis of lignin and a variety of phytochemicals. Coniferyl alcohol is an inhibitor of S-adenosyl-homocysteine hydrolase (SAAH) in vitro (IC50 = 34 nM). It increases the...

Protein function: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions, therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. [The UniProt Consortium]

Protein function: May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). [The UniProt Consortium]

Active human AHCY (human S-adenosyl homocysteine hydrolase) (GenBank Accession No. NM_000687), (amino acids 2-end) with N-terminal GST tag, MW = 73 kDa, expressed in an E Coli expression system.