76 products were found matching "K01201"!

Description: GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439.

An activator of GCase (AC50 = 1.49 µM), increases GCase protein levels and activity and reduces mutant GCase protein misfolding in GBA1N370S/84GG-expressing patient-derived fibroblasts from patients with Gaucher disease, increases GCase protein levels and activity in iPSC-derived and GBA1N370S-expressing iPSCs...

Beta-Glucosylceramidase (beta-GC) is a lysosomal enzyme that catalyzes the hydrolysis of glucocerebroside into free ceramide and glucose. Lysosomal breakdown of glucocerebroside is required for cellular metabolism of complex lipids and proper turnover of cellular membrane. In the absence of GBA, the gene that...

Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid beta-glucosidase, glucosylceramidase, GBA, or GBA1 (IC50 = 9 µM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or...

NCGC607 is a salicylic acid derivative and small molecule glucocerebrosidase (GCase) chaperone. A mutation in the GCase gene is found in patients with Gaucher disease and is the most common genetic risk factor for Parkinson's disease. In induced pluripotent stem cell-derived (iPSC) macrophages from patients with...

Isofagomine (D-tartrate) is a competitive inhibitor of human lysosomal beta-glucosidase (Ki = 0.016-0.025 µM, IC50 = 0.06 µM). By interacting with the catalytic pocket of beta-glucosidase it acts as a chemical chaperone that increases the amount of beta-glucosidase by stabilizing and/or promoting the folding of the...

1-beta-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides (Cay-23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of...

LTI-291 is a CNS-penetrant allosteric activator of glucocerebrosidase (GCase). It increases the activity of wild-type human GCase by 25 and 130% when used at concentrations of 0.1 and 1 µM, respectively.Formal Name: 5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide. CAS Number:...

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. [RefSeq] Protein function: Glucosylceramidase that catalyzes, within the lysosomal...

Protein function: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes...