80 products were found matching "K01115"!

An inhibitor of PLD1, inhibits PLD activity in PLD1-overexpressing A549 cells (IC50 = 1.97 µM), reduces the viability of A549 and HCT116 cell (IC50s = 18 and 29 µM, respectively), inhibits the proliferation, migration, and invasion of A549 cells and induces apoptosis in the same cells, reduces tumor growth, induces...

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...

VU036739 is an inhibitor of phospholipase D2 (PLD2, IC50 = 20 nM). It is selective for PLD2 over PLD1 (IC50 = 1,500 nM). VU036739 (10 µM) induces apoptosis in MDA-MB-231 breast cancer cells. It decreases levels of deoxyribonucleoside triphosphates in serum-starved U87MG glioma cells when used at a concentration of 5...

Protein function: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. [The UniProt Consortium]

Phospholipase D (PLD) is an enzyme that cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1, and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...

Halopemide is a potent inhibitor of phospholipase D (PLD), inhibiting human PLD1 and PLD2 in vitro (IC50 = 220 and 310 nM, respectively) and PLD activity in cells. Previously, halopemide has been found to inhibit dopamine receptors and was evaluated as a neuroleptic agent.Formal Name:...

ML-299 is a dual inhibitor of phospholipase D1 (PLD1) and PLD2 (IC50s = 6 and 20 nM, respectively). It is selective for PLD1 and PLD2 over a panel of 65 receptors but also inhibits human-ether-a-go-go (hERG), also known as Kv11.1, as well as kappa- and µ-opioid receptors at 10 µM. ML-299 (1 and 10 µM) decreases...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. By somatic cell hybrid analysis, PLD1 is mapped to 3q26.31. This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal...

ML-298 is an inhibitor of phospholipase D2 (PLD2, IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 µM without inducing cytotoxicity.Formal Name:...