- Search results for K01103
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36 products were found matching "K01103"!
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Item number: Cay19276-5
3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3, IC50 = 23 µM) that causes a rapid reduction in fructose-2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion. This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in...
Keywords: | 3-(3-pyridinyl)-1-(4-pyridinyl)-2E-propen-1-one |
Application: | PFKFB3 inhibitor |
CAS | 18550-98-6 |
MW: | 210.2 D |
From 50.00€
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Item number: Cay22987-5
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3, IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 µM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 µM for Jurkat cells)...
Keywords: | 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2E-quinolinyl]-2-propen-1-one |
Application: | PFKFB3 inhibitor |
CAS | 1462249-75-7 |
MW: | 328.3 D |
From 77.00€
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Item number: Cay17689-5
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a bifunctional enzyme that contains distinct domains for the phosphorylation of fructose 6-phosphate and the dephosphorylation of fructose 2,6-bisphosphate. PFKFB3 protein expression is elevated in most tumor types. PFK15 is a selective inhibitor of...
Keywords: | 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one |
Application: | PFKFB3 inhibitor |
CAS | 4382-63-2 |
MW: | 260.3 D |
From 60.00€
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Item number: Cay15352-5
Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs. During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction...
Keywords: | 7-hydroxycoumarin-3-Carboxylic Acid ethyl ester, 7-hydroxy-2-ozo-2H-1-benzopyran-3-carboxylic acid, ethyl ester |
Application: | PFKFB3 inhibitor |
CAS | 6093-71-6 |
MW: | 234.2 D |
From 43.00€
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Item number: A304-248A
Protein function: Synthesis and degradation of fructose 2,6-bisphosphate. [The UniProt Consortium]
Keywords: | Anti-iPFK-2, Anti-PFKFB3, EC=3.1.3.46, EC=2.7.1.105, Anti-PFK/FBPase 3, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: A304-249A
Protein function: Synthesis and degradation of fructose 2,6-bisphosphate. [The UniProt Consortium]
Keywords: | Anti-iPFK-2, Anti-PFKFB3, EC=3.1.3.46, EC=2.7.1.105, Anti-PFK/FBPase 3, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: BPS-71089
Human 6-phosphofructo-2-kinase/ fructose-2,6-biphosphatase 3, also known as PFKFB3 and IPFK2, (GenBank Accession No. NM_004566), amino acids 2-520(end)) with N-terminal His-tag, MW = 60.4 kDa, expressed in an E. coli cell expression system.
Keywords: | PFKFB3, iPFK-2, PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase 3, 6-phosphofructo-2-kinase, Fructose-2,6-bisphosphatase, Renal... |
Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Expressed in: | E.coli |
Origin: | human |
MW: | 60.4 kD |
547.00€
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Item number: NSJ-F51072-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...
Keywords: | Anti-iPFK-2, Anti-PFKFB3, EC=3.1.3.46, EC=2.7.1.105, Anti-PFK/FBPase 3, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | WB, IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human |
From 326.00€
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Item number: ARG54872.100
Protein function: Synthesis and degradation of fructose 2,6-bisphosphate. [The UniProt Consortium]
Keywords: | Anti-PFKFB3, Anti-iPFK-2, EC=3.1.3.46, Anti-PFK/FBPase 3, EC=2.7.1.105, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | IHC (paraffin), WB |
Host: | Rabbit |
Species reactivity: | human |
624.00€
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Item number: E-AB-19543.120
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of...
Keywords: | Anti-PFKFB3, Anti-iPFK-2, EC=3.1.3.46, Anti-PFK/FBPase 3, EC=2.7.1.105, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | WB, ELISA |
Host: | Rabbit |
Species reactivity: | human, rat |
From 71.00€
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Item number: E-AB-53523.120
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of...
Keywords: | Anti-PFKFB3, Anti-iPFK-2, EC=3.1.3.46, Anti-PFK/FBPase 3, EC=2.7.1.105, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | WB, ELISA |
Host: | Rabbit |
Species reactivity: | human, rat |
From 71.00€
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Item number: E-AB-66342.120
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of...
Keywords: | Anti-PFKFB3, Anti-iPFK-2, EC=3.1.3.46, EC=2.7.1.105, Anti-PFK/FBPase 3, Anti-6PF-2-K/Fru-2,6-P2ase 3,... |
Application: | IF |
Host: | Rabbit |
Species reactivity: | human, mouse |
From 198.00€
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