39 products were found matching "K00569"!

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct.

6-Methylmercaptopurine (6-MMP) is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine (6-MP, Cay-23675). It is formed from 6-MP via methylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with...

Protein function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. [The UniProt Consortium]

Protein function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6- TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates...

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with...

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with...

ELISA Type: Sandwich. Sensitivity: 1.875ng/mL . Range: 3.125--200ng/mL . Protein function: Catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S- adenosyl-L-methionine as the...

Protein function: Catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S- adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates...

6-Methylmercaptopurine-d3 (6-MMP-d3) is intended for use as an internal standard for the quantification of 6-MMP (Cay-34356) by GC- or LC-MS. 6-MMP is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine (6-MP, Cay-23675). It is formed from 6-MP via methylation by thiopurine...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TPMT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TPMT. Next,...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 4-244aa. Protein Length: Partial. Tag Info: N-terminal GST-tagged. Target Protein Sequence: TRTSLDIEEY SDTEVQKNQV LTLEEWQDKW VNGKTAFHQE QGHQLLKKHL DTFLKGKSGL RVFFPLCGKA VEMKWFADRG HSVVGVEISE LGIQEFFTEQ NLSYSEEPIT EIPGTKVFKS SSGNISLYCC SIFDLPRTNI...