113 products were found matching "K00545"!

Protein function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. [The UniProt Consortium]

2-methoxy Estrone is an active metabolite of the endogenous estrogen estrone (Cay-10006485). It is formed from estrone by catechol-O-methyltransferase (COMT). 2-methoxy Estrone inhibits the proliferation of isolated bovine brain-derived capillary endothelial cells (IC50 = 11.5 µM). It increases the levels of 6-keto...

Entacapone is a reversible catechol O-methyltransferase (COMT) inhibitor (IC50s = 10, 10, 20, and 160 nM for rat duodenum, brain, erythrocyte, and liver COMT, respectively). It is selective for COMT over monoamine oxidase A (MAO-A) and MAO-B and phenolsulphotransferase M (PST-M) and PST-P (IC50s = >50 µM)....

Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT, Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Cay-13248). Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity. By inhibiting...

3-methoxy Tyramine is a natural metabolite of dopamine, produced by catechol O-methyltransferase (COMT). It is a weak agonist of trace amine-associated receptor 1 (EC50 = 1.7 µM). 3-methoxy Tyramine levels are assessed to monitor COMT activity in Parkinson's disease. Elevated 3-methoxy Tyramine levels may also...

Metanephrine is an inactive metabolite of epinephrine (Cay-21245). It is formed from epinephrine by catechol-O-methyl transferase (COMT). Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.Formal Name:...

Tolcapone-d4 is intended for use as an internal standard for the quantification of tolcapone (Cay-20768) by GC- or LC-MS. Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT, Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine (Cay-21992) and...

Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Cay-20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S....

Description: Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor employed as an adjunctive therapy with levodopa and carbidopa in the treatment of Parkinson's disease. Target: Apoptosis, Transferase, Beta Amyloid. Smiles: C(=O)(C1=CC(N(=O)=O)=C(O)C(O)=C1)C2=CC=C(C)C=C2. References: Zürcher G, et al....

S-Catechol-O-methyltransferase (S-COMT) is the soluble cytosolic form of COMT. A rough endoplasmic reticulum membrane-bound form of COMT (MB-COMT) is also encoded by the COMT gene but produced via a separate promoter and contains an additional 50 amino acid residues, which compose the membrane anchor region. COMT is...

3-O-methyl-L-DOPA is an active metabolite of L-DOPA (Cay-13248). It is formed from L-DOPA via O-methylation by catechol-O-methyltransferase (COMT). 3-O-methyl-L-DOPA (10 and 100 µM) inhibits L-DOPA-induced neuroprotection in primary rat mesencephalic dopaminergic neurons.Formal Name: 3-methoxy-L-tyrosine,...

3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM). It is selective for COMT over tyrosine hydroxylase, dopamine beta-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 µM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with...