34 products were found matching "K00497"!

Rabbit Polyclonal CYP11B1 Antibody against Human cytochrome P450 family 11 subfamily B member 1. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000023043:...

Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11beta-hydroxylase (IC50 = 7.83 µM), an enzyme involved in the final step of cortisol biosynthesis. It also induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11beta-hydroxysteroid dehydrogenase type 1...

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11beta-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with...

21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11beta-hydroxylase. Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cytochrome p450, family 11, subfamily B, polypeptide 1, also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to...

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. CYP11B1 shows close homology to the CYP11B2 gene, which encodes aldosterone synthase and is normally expressed only in the zona glomerulosa. Both genes map to chromosome 8q21. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The...

Protein function: A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:18215163). Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively...

Protein function: A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:18215163). Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively...

21-Deoxycortisol-d8 is intended for use as an internal standard for the quantification of 21-deoxycortisol (Cay-30873) by GC- or LC-MS. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11beta-hydroxylase. Serum levels of 21-deoxycortisol...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 25-503aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Target Protein Sequence: GTRAARVPRT VLPFEAMPRR PGNRWLRLLQ IWREQGYEDL HLEVHQTFQE LGPIFRYDLG GAGMVCVMLP EDVEKLQQVD SLHPHRMSLE...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 25-503aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: GTRAARVPRT VLPFEAMPRR PGNRWLRLLQ IWREQGYEDL HLEVHQTFQE LGPIFRYDLG GAGMVCVMLP EDVEKLQQVD SLHPHRMSLE PWVAYRQHRG HKCGVFLLNG PEWRFNRLRL...