87 products were found matching "K00355"!

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that plays a central role in cellular defense against oxidative stress. As a 2-electron reductase, NQO1 catalyzes the reduction of quinones to hydroquinones, thereby preventing the formation of...

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 1-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of...

A quinone with enzyme inhibitory and anti-inflammatory activities, inhibits NQO1 (IC50 = 131.5 nM), inhibits bradykinin-induced PGE2, 6-keto PGF1alpha, and PGD2 production in SW 982 cells (IC50s = 9, 19, and 7 nM, respectively), induces ROS production in SW 982 cells. Formulation: A powder. InChI:...

An NQO1 inhibitor (IC50 = 83.3 nM). Formulation: A powder. InChI: InChI=1S/C14H10N2O2S/c17-12-6-11(13(18)10-8-16-19-14(10)12)15-7-9-4-2-1-3-5-9/h1-6,8,15H,7H2. InChIKey: REQNSASITZCQGJ-UHFFFAOYSA-N. SMILES: O=C1C=C(C(C2=C1SN=C2)=O)NCC3=CC=CC=C3

beta-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 µM and transglutaminase (IC50 = 5 µM). In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, beta-lapachone is reduced to beta-lapachone hydroquinone, which generates reactive...

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin...

(±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities. (±)-Dunnione also reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 µM). It is a substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) that increases production of reactive oxygen species (ROS) and induces cell death of...

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of...

Recognizes human NQO1. Detects a band of about 30kDa by Western blot. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD(P)H as an electron...

Protein function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. [The UniProt...