21 products were found matching "K00308"!

N1-Acetylspermidine is an acetyl derivative of spermidine (Cay-14918) that acts as a substrate for polyamine oxidase (PAO). In peroxisomes, PAO oxidizes N1-acetylspermidine to 3-acetamidopropanal and putrescine, a positively charged polyamine that binds DNA and is involved in various cellular processes including...

A monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Formulation: A crystalline solid. InChI:...

N1-Acetylspermine is a monoacetylated derivative of spermine (Cay-18041), an endogenous polyamine synthesized from spermidine (Cay-14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for...

MDL 72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively). It does not inhibit monoamine oxidase or D-amino acid oxidase. MDL 72527 inhibits PAO-dependent H2O2 production in vitro and in vivo and is used to study the role of...

Description: N1-Acetylspermidine hydrochloride, an acetyl derivative of spermidine, serves as a substrate for polyamine oxidase and selectively elevates its levels in human colorectal adenocarcinomas. Target: Endogenous Metabolite. Smiles: O=C(C)NCCCNCCCCN.Cl.Cl. References: Gawandi, V., and Fitzpatrick, P.F. The...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PAOX. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PAOX. Next,...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Description: N1-Acetylspermine trihydrochloride is a monoacetylated derivative of spermine which is an endogenous polyamine. N1-Acetylspermine trihydrochloride can be used in studies about the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16. Target: Endogenous...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

PAOX is widely expreesed and not detected in spleen tissue. Expressed at lower level in neoplastic tissues. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Immunohistochemistry (FFPE): 1:50-1:100, Optimal...

Polyamine Oxidase (PAOX) BioAssayT ELISA Kit (Mouse) is a sandwich enzyme immunoassay for in vitro quantitative measurement of PAOX in mouse serum, plasma, tissue homogenates and other biological fluids. Detection Range: 78-5,000pg/ml, Sensitivity: 32pg/ml, Storage and Stability: Desiccation recommended. The...