- Search results for K00254
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40 products were found matching "K00254"!
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Item number: ELK-ELK6762.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse DHODH. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse DHODH. Next,...
Keywords: | Dhodh, DHOdehase, Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: ELK-ELK3713.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DHODH. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DHODH. Next,...
Keywords: | DHODH, DHOdehase, Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay37728-1
PfDHODH-IN-1 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50s = 190, 47, and 21 nM for the human, mouse, and rat enzymes, respectively) and a derivative of the DHODH inhibitor A-771726 (Cay-14404). It inhibits delayed-type hypersensitivity reactions in mice and rats when administered at doses of 30 and...
Keywords: | CCHTFP, PfDHODH Inhibitor 1, 2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-propenamide |
Application: | DHODH inhibitor |
CAS | 183945-55-3 |
MW: | 296.2 D |
From 35.00€
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Item number: Cay14860-25
Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of...
Keywords: | Arava, HW 486, SU 101, 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide |
Application: | Immunosuppressant, Pyrimidine synthesis inhibitor, Dihydroorotate dehydrogenase inhibitor |
CAS | 75706-12-6 |
MW: | 270.2 D |
From 43.00€
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Item number: Cay24445-1
Brequinar is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = ~20 nM), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. Brequinar is selective for DHODH over a panel of greater than 400 kinases at 100 nM. It induces differentiation of ER-HoxA9, U937, and THP-1 cells...
Keywords: | NSC 368390, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid |
Application: | DHODH inhibitor |
CAS | 96187-53-0 |
MW: | 375.4 D |
From 43.00€
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Item number: Cay18377-10
Dihydroorotate dehydrogenase (DHODH) is involved in pyrimidine nucleoside biosynthesis. DHODH inhibitors have value in autoimmune diseases as well as cancer and certain infections. Vidofludimus is an immunosuppressive drug that inhibits DHODH (IC50s = 0.134, 1.29, and 10.6 µM for human, rat, and mouse isoforms,...
Keywords: | 4SC-101, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid |
Application: | Dihydroorotate dehydrogenase (DHODH) inhibitor |
CAS | 717824-30-1 |
MW: | 355.4 D |
From 50.00€
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Item number: Cay33259-1
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 1.2 nM). It induces upregulation of the cell differentiation marker CD11b in MOLM-13 and HEL acute myeloid leukemia (AML) cells (EC50s = 3.16 and 0.96 nM, respectively) and inhibits the proliferation of nine leukemia cell lines (IC50s =...
Keywords: | N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-5-fluoro-2-[(1S)-2,2,2-t... |
Application: | DHODH inhibitor |
CAS | 2225819-06-5 |
MW: | 520.8 D |
From 130.00€
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Item number: Cay14404-25
A-771726 is an active metabolite of the prodrug leflunomide (Cay-14860) that inhibits dihydroorotate dehydrogenase (DHODH, IC50 = 0.23 µM). A-771726 inhibits the production of prostaglandin E2 (PGE2, Cay-14010) in TNF-alpha- or IL-1alpha-stimulated isolated human synoviocytes (IC50s = 7 and 3 µM, respectively). It...
Keywords: | Flucyamide, HMR 1726, SU 20, Teriflunomide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide |
Application: | Dihydroorotate dehydrogenase inhibitor, Tyrosine kinase inhibitor |
CAS | 163451-81-8 |
MW: | 270.2 D |
From 84.00€
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Item number: Cay33516-10
ASLAN003 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 35 nM). It inhibits the proliferation of MOLM-14 and KG-1 acute myeloid leukemia (AML) cells (IC50s = 0.582 and 0.382 µM, respectively), as well as induces apoptosis in the same cells when used at concentrations of 0.5 and 1 µM. ASLAN003 (1, 2,...
Keywords: | 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-3-pyridinecarboxylic acid |
Application: | DHODH inhibitor |
CAS | 1035688-66-4 |
MW: | 356.3 D |
From 60.00€
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Item number: LKT-L1817.1
Leflunomide is a pyrimidine biosynthesis inhibitor. It is an established disease-modifying antirheumatic drug. It has been approved for treatment of rheumatoid arthritis (RA) and may also be useful in treating patients with Felty´s syndrome. It is suggested that supression of TNF signalling is one of the...
Keywords: | HWA-486 |
Application: | Pyrimidine biosynthesis inhibitor |
CAS | 75706-12-6 |
MW: | 270,21 D |
From 135.00€
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Item number: Cay21395-10
ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390...
Keywords: | N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-benzamide |
Application: | DHODH inhibitor |
CAS | 2029049-79-2 |
MW: | 406.4 D |
From 66.00€
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Item number: Cay26448-1
Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide (Cay-14860) by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T...
Keywords: | 5-methyl-N-(4-(trifluoromethyl)phenyl-2,3,5,6-d4)isoxazole-4-carboxamide |
Application: | GC-MS, LC-MS, quantification, internal standard, dihydroorotate dehydrogenase inhibitor |
CAS | 1189987-23-2 |
MW: | 274.2 D |
From 176.00€
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