76 products were found matching "K00106"!

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Xanthine dehydrogenase, also known as XDH, is a protein that, in humans, is encoded by the XDH gene. Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been...

Xanthine oxidase (XO) catalyzes the hydroxylation of hypoxanthine to xanthine and then further catalyzes the oxidation of xanthine to uric acid. When oxidizing NADH, XO generates superoxide, a powerful reactive oxygen species. Excessive amounts of superoxide can lead to cell degeneration and death. XO is found...

Xanthine oxidase (XO) is a complex metalloflavoprotein involved in purine catabolism, oxidative stress, and xenobiotic metabolism, among other processes. It exists as a homodimer and each monomer is composed of an N-terminal domain that contains two unequal iron-sulfur clusters, an intermediate domain that contains...

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and...

Xanthine oxidase inhibitor.

Lucigenin is a chemiluminescent probe used to detect superoxide production and the presence of chloride. It can be used to detect superoxide production by enzymatic and cellular sources. It is a sensitive method that has been applied to the monitoring of superoxide production from xanthine oxidase, microsomal NADPH...

1,7-Dimethyluric acid is a metabolite of caffeine (Cay-14118) produced by the action of xanthine oxidase on paraxanthine. It can be detected in urine as a biomarker of caffeine consumption.Formal Name: 7,9-dihydro-1,7-dimethyl-1H-purine-2,6,8(3H)-trione. CAS Number: 33868-03-0. Synonyms: 1,7-DMUA. Molecular Formula:...

Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the...

Xanthine is a purine base and intermediate in the biosynthesis of uric acid (Cay-16219). It is formed during mammalian purine catabolism in the liver via oxidation of hypoxanthine (Cay-22254) by xanthine oxidase (XO), which also oxidizes xanthine to produce uric acid. Xanthine is also formed from guanine,...

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase. The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide. Uric acid acts as a potent...

Allopurinol is a purine analog that mimics hypoxanthine, inhibiting xanthine oxidase, it is clinically used to treat diseases of hyperuricemia, such as gout. Allopurinol exhibits anti-inflammatory, nephroprotective, antinociceptive, antioxidative, anti-fibrotic, and cardioprotective activities. In animal models of...

Oxipurinol is an inhibitor of xanthine oxidase and active metabolite of the xanthine oxidase inhibitor allopurinol (Cay-10012597). Oxipurinol is formed by the oxidation of allopurinol and binds to an enzyme-bound molybdenum cofactor that keeps xanthine oxidase in an inactive state. It inhibits de novo purine and...