91 products were found matching "GeneID 7249"!

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-Tuberin (Ser939) antibody detects the phosphorylated form of Tuberin, encoded by the TSC2 gene. Tuberin is a large cytoplasmic protein that forms a functional complex with Hamartin, encoded by...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic...

Protein function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase...

Protein function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct...

Protein function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase...

Protein function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase...

Anti-TSLP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TSLP from other sources has not been determined. Protein function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by...

Anti-TSLP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TSLP from other sources has not been determined. Protein function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tuberous sclerosis 2, also known as TSC2 or Tuberin is a protein that is in humans. Mutations in this gene lead to tuberous sclerosis complex. TSC2 is believed to be a tumor suppressor and is able to stimulate specific GTPases. It associates with hamartin in a...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative...