- Search results for GeneID 51185
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19 products were found matching "GeneID 51185"!
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Item number: ELK-ELK4870.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CRBN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CRBN. Next,...
Keywords: | CRBN, AD-006, Protein cereblon |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: ARG44026.50
Protein function: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and...
Keywords: | Anti-CRBN, Anti-AD-006, Anti-Protein cereblon, Anti-Protein cereblon |
Application: | IHC (paraffin), WB |
Host: | Rabbit |
Species reactivity: | human, rat |
544.00€
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Item number: BPS-79899
The Cereblon Binding Assay Kit (FP) is designed for testing and profiling of Cereblon (CRBN) inhibitors using Fluorescence Polarization. The assay is a competitive binding assay, based on the binding of fluorescently-labeled Thalidomide, a CRBN binder, to purified recombinant CRBN. CRBN is the substrate recognition...
Keywords: | CRBN, AD-006, Protein cereblon |
Application: | Enzyme kinetics, drug discovery, HTS |
Species reactivity: | human |
883.00€
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Item number: BPS-100329-1
Cereblon/DDB1/Cul4A/Rbx1 complex of human Cereblon (GenBank Accession No. NM_016302) a.a. 2-442(end) with N-terminal FLAG-tag and MW= 51 kDa, human DDB1 (GenBank Accession No. NM_001923), a.a. 1-1140(end) with N-terminal FLAG-tag and MW= 128 kDa, human Cul4A (GenBank Accession No. NM_003589), a.a. 2-759(end) with...
Keywords: | CRBN, AD-006, Protein cereblon, |
Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Expressed in: | human cells |
Origin: | human |
MW: | 51/128/87... kD |
From 378.00€
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Item number: BPS-79881
The Cereblon Ubiquitination Homogeneous Assay Kit is designed to measure Cereblon auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled ubiquitin and proper A-screen beads to complete the pairing. This homogeneous assay requires no time-consuming washing steps, making it...
Keywords: | CRBN, AD-006, Protein cereblon |
Application: | Small molecular inhibitor/PROTAC screening, drug discovery, HTS |
Species reactivity: | human |
1,202.00€
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Item number: 600-401-AN1
Anti-CRBN antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist, this antibody will detect both isoforms. Protein function: Substrate recognition component of a DCX (DDB1-CUL4-X-...
Keywords: | Anti-CRBN, Anti-AD-006, Anti-Protein cereblon |
Application: | ELISA, WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
684.00€
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Item number: BPS-79770
The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding is designed for testing and profiling of PROTACs directed against BET Bromodomain family and Cereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination...
Keywords: | CRBN, Protein X 0001, MRT2A MRT2, |
Application: | Protac |
Species reactivity: | human |
1,453.00€
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Item number: ARG59917.100
Protein function: Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the...
Keywords: | Anti-CRBN, Anti-AD-006, Anti-Protein cereblon |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
624.00€
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Item number: BPS-79924
The PROTAC Optimization Kit for CDK Kinase-Cereblon Binding is designed for testing and profiling of PROTACs directed against the CDK Kinase family and Cereblon. Cereblon (CRBN) is a Substrate recognition component of the DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent...
Keywords: | CRBN, AD-006, Protein cereblon |
Application: | PROTAC optimization |
Species reactivity: | human |
1,259.00€
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Item number: BPS-78301
Covalent conjugation to ubiquitin (Ub) is one of the major post-translational modifications that regulates protein stability, function, and localization. Ubiquitination is the concerted action of three enzymes: a Ub-activating enzyme (E1), a Ub-conjugating enzyme (E2), and a Ub ligase (E3). The specificity and...
Keywords: | CRBN, MRT2A, MRT2, TR-FRET Kit, Homogeneous Kit, |
Application: | Small molecule screening, drug discovery, HTS, kinetics |
Species reactivity: | human |
2,518.00€
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Item number: ATA-HPA045910.100
Protein function: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and...
Keywords: | Anti-CRBN, Anti-AD-006, Anti-Protein cereblon |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 300.00€
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Item number: BPS-100255-1
Recombinant human cereblon (CRBN), full length, encompassing amino acids 2-422(end). This construct contains an N-terminal Flag-tag. The recombinant protein was affinity purified.
Keywords: | CRBN, AD-006, Protein cereblon, |
Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
Expressed in: | human cells |
Origin: | human |
MW: | 52+glyc kD |
From 348.00€
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