Streptolysin O, isolated from human plasma. Streptolysin-O (SLO) is a bacterial protein that forms an alpha helix and is toxic to eukaryotic cells. Its toxic effect is due to the protein's ability to bind to cholesterol and form holes in the plasma membrane of cells. This ability can be utilized in the laboratory to...

Streptolysin-O (SLO) is a bacterial protein that forms an alpha helix and is toxic to eukaryotic cells. Its toxic effect is due to the protein's ability to bind to cholesterol and form holes in the plasma membrane of cells. This ability can be utilized in the laboratory to create holes in the plasma membrane but not...

Description: Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state . Target: Others. References: Sierig G, et al. Cytotoxic...