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IMD 0354
IMD 0354

Item number: Cay17290-1

IMD 0354 is an IKKbeta (IKK2) inhibitor that blocks NF-kappaB phosphorylation (IC50 = ~250 nM) and subsequent NF-kappaB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1beta and MCP-1 production,...
Keywords: IKK2 Inhibitor V, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide
Application: IKK2 inhibitor
CAS 978-62-1
MW: 383.7 D
From 56.00€ *
Review
IMD-0354
IMD-0354

Item number: TGM-T6141-100mg

Description: IMD-0354 (IKK2 Inhibitor V) is an IKKbeta inhibitor that blocks IkappaBalpha phosphorylation in the NF-kappaB pathway. Target: IkappaB/IKK. Smiles: Oc1ccc(Cl)cc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F. References: Tanaka A, et al. Blood, 2005, 105(6), 2324-2331.
Keywords: IMD 0354, IKK2 Inhibitor V
Application: IKK2 inhibitor
CAS 978-62-1
MW: 383.67 D
From 39.00€ *
Review