Isolated from Nonomuraea longicatena chiba. Antibiotic. PKC, PKA and PKG inhibitor. Shows neurotropic activity by inducing neurite outgrowth. Highly potent cell permeable CaM kinase and phosphorylase inhibitor. Tyrosine protein kinase inhibitor of the TRK family. Antiproliferative. Apoptosis inducer. Cell cycle...

K252a is a kinase inhibitor that inhibits PKA (Ki=18nM), PKC (Ki=25nM), and PKG (Ki=20nM). Solubility: Soluble in DMSO at 100mg/ml, poorly soluble in ethanol. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the...

K252a is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC. K252a also inhibits TrkA/B receptors, suppressing activity of neurotrophins such as nerve growth factor (NGF).