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Item number: Cay17204-1

alpha-hydroxy Tamoxifen is a reactive metabolite of the estrogen receptor (ER) modulator tamoxifen (Cay-13258) that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which...

Keywords:	(betaE)-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-alpha-methyl-benzeneethanol
Application:	Reactive tamoxifen metabolite
CAS	97151-02-5
MW:	387.5 D

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alpha-Hydroxytamoxifen

Item number: TGM-T19192-10mg

Description: alpha-Hydroxytamoxifen, a metabolite of tamoxifen, reacts with DNA and forms DNA adducts. Target: Others. Smiles: C(=C(/C(C)O)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3. References: Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity...

Keywords:	alpha-OHTAM, (E)-alpha-Hydroxy tamoxifen
Application:	Reactive tamoxifen metabolite
CAS	97151-02-5
MW:	387.51 D

From 74.00€ *

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