PD 117519 is an adenosine receptor agonist. It selectively binds to adenosine A2 receptors (IC50 = 30 µM) over A1 receptors (IC50 = 810 µM) in rat brain membranes. PD 117519 increases heart rate and decreases systolic blood pressure in normotensive dogs when administered at doses of 2 or 10 mg/kg.Formal Name:...

Description: PD 117519 (CI947) is an agonist of the adenosine receptor. Target: Adenosine Receptor. Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3Cc4ccccc4C3)ncnc12. References: Enerson B , Lin A , Lu B , et al. Acute Drug-Induced Vascular Injury in Beagle Dogs: Pathology and Correlating Genomic Expression[J]....