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SM-164
Item number: Cay28632-500
SM-164 is a cell-permeable bivalent mimetic of Smac and an inhibitor of X-linked inhibitor of apoptosis (XIAP). It binds to BIR2 and BIR3 domain-containing XIAP with an IC50 value of 1.39 nM and interacts with both domains. SM-164 inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and...
| Keywords: | (3S,3'S,6S,6'S,10aS,10'aS)-N,N'-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[deca... |
| Application: | Cell-permeable bivalent Smac mimetic, XIAP inhibitor |
| CAS | 957135-43-2 |
| MW: | 1121.4 D |
From 147.00€
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SM-164
Item number: TGM-T12932L-10mg
Description: SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP. Target: Apoptosis, IAP. Smiles:...
| Application: | Cell-permeable bivalent Smac mimetic, XIAP inhibitor |
| CAS | 957135-43-2 |
| MW: | 1121.42 D |
From 112.00€
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