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Item number: Cay17931-1

PF-04217903 is an inhibitor of c-Met (Ki = 4.8 nM). It is greater than 1,000-fold selective for c-Met over a panel of 150 kinases. PF-04217903 inhibits the proliferation of and induces apoptosis in GTL-16 gastric carcinoma cells (IC50s = 12 and 31 nM, respectively) as well as inhibits migration of NCI H441 lung...

Keywords:	4-[1-(6-quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol
Application:	c-Met kinase inhibitor
CAS	956905-27-4
MW:	372.4 D

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PF-04217903

Item number: SYN-1060-M001

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM. Target: MET , Kinase Group: RTK , Substrate: Tyrosine

Keywords:	PF04217903
Application:	MET inhibitor
CAS	956905-27-4
MW:	372,4 D

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