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Adavosertib
Item number: TGM-T2077-100mg
Description: Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint. Target: Wee1. Smiles: C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C(C(C)(C)O)C=CC5. References: Hirai H, et al. Small-molecule inhibition of Wee1...
| Keywords: | MK-1775, AZD1775, Adavosertib (MK-1775) |
| Application: | Targets wee1-like protein kinase [EC:2.7.11.1] (WEE1) |
| CAS | 955365-80-7 |
| MW: | 500.6 D |
From 42.00€
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MK-1775
Item number: Cay21266-5
MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM). It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the G2 DNA damage checkpoint. In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging...
| Keywords: | AZD 1775,... |
| Application: | Wee1 inhibitor |
| CAS | 955365-80-7 |
| MW: | 500.6 D |
From 61.00€
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MK-1775
Item number: LKT-M4102.1
Wee1 inhibitor.
| Application: | Wee1 inhibitor |
| CAS | 955365-80-7 |
| MW: | 500.6 D |
From 95.00€
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MK-1775
Item number: BPS-82196
MK-1775, also known as Adavosertib and AZD1775, is a potent and selective inhibitor of Wee1 with IC50 of 5.2 nM
| Keywords: | Adavosertib, AZD1775,... |
| Application: | Wee1 inhibitor |
| CAS | 955365-80-7 |
| MW: | 500,6 D |
432.00€
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