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PF 477736
Item number: TGM-T6028-10mg
Description: PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. Target: VEGFR, FGFR, Src, c-Fms, CDK, Chk, c-RET, FLT, Aurora Kinase. Smiles:...
| Keywords: | PF477736, PF-736,PF-00477736, PF 00477736, PF-477736 |
| Application: | ATP-competitive Chk1 inhibitor |
| CAS | 952021-60-2 |
| MW: | 419.48 D |
From 45.00€
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PF-477736
Item number: Cay17859-5
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA...
| Keywords: | (alphaR)-amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexanea... |
| Application: | ATP-competitive Chk1 inhibitor |
| CAS | 952021-60-2 |
| MW: | 419.5 D |
From 145.00€
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PF-0477736
Item number: AG-CR1-3537-M005
PF-0477736 is a potent, selective ATP-competitive inhibitor of Chk1 (Ki = 0.49nM) with 100-fold selectivity over Chk2 (Ki = 47nM). When used in combination with various chemotherapeutics (e.g. gemcitabine and carboplatin), PF-0477736 abrogates DNA damage-induced cell cycle arrest, sensitizes cells to DNA damage,...
| CAS | 952021-60-2 |
From 77.00€
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