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Item number: Cay42734-10

Timapiprant is a DP2 receptor antagonist (Ki = 0. µM). It is selective for DP2 over the additional prostanoid receptors DP1, TP, EP1-4, FP, and IP (Kis = >10 µM for all). Timapiprant inhibits calcium mobilization induced by prostaglandin D2 (PGD2, Cay-12010) in CHO cells expressing human DP2 (IC50 = 0. µM). It...

Keywords:	OC000459, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid, monosodium salt
Application:	Prostaglandin D2 receptor (PTGDR) antagonist
CAS	950688-14-9
MW:	370.36 D

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Timapiprant sodium

Item number: TGM-T17099-1mL

Description: Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), human native DP2...

Keywords:	OC000459 sodium
CAS	950688-14-9
MW:	371.367 D

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