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2-Acetyl-5-tetrahydroxybutyl Imidazole
2-Acetyl-5-tetrahydroxybutyl Imidazole

Item number: Cay13222-1

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo. THI is not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation. In mice, THI (50 µg/ml in drinking water) increases S1P...
Keywords: 2-Acetyl-4-tetrahydroxybutyl Imidazole, 2-ATHBI, THI, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone
Application: S1P lyase inhibitor
CAS 94944-70-4
MW: 230.2 D
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