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MNI137
Item number: Cay45486-10
MNI137 is a negative allosteric modulator of metabotropic glutamate receptor 2 (mGluR2). It selectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing human mGluR2 (IC50 = 11.4 nM) over HEK293 cells expressing rat mGluR1, -5, -7, or -8 and those expressing human mGluR4 at 10 µM.. SMILES:...
| Keywords: | 4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile |
| Application: | MGluR2 negative allosteric modulator |
| CAS | 946619-21-2 |
| MW: | 341.17 D |
From 124.00€
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MNI 137
Item number: TGM-T23010-100mg
Description: MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat. Target: GluR. Smiles: O=C1NC=2C(N=C(C1)C=3C=C(C#N)N=CC3)=CC=C(Br)C2
| CAS | 946619-21-2 |
| MW: | 341.16 D |
From 46.00€
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