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Item number: TGM-T6940-100mg

Description: PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-beta and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1. Target: GSK-3, CDK, Apoptosis....

Keywords:	CAY-10572 hydrochloride, CAY10572, PHA-767491, PHA767491 HCl
Application:	Cdc7 kinase inhibitor
CAS	942425-68-5
MW:	249.69 D

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PHA-767491 (hydrochloride)

Item number: Cay18218-10

Cdc7 kinase is a key regulator of the S-phase of the cell cycle. It is known to promote the activity of DNA replication origins in eukaryotic organisms. Inhibition of Cdc7 kinase causes blockade of DNA synthesis in human cell lines. Tumor cells are then funneled into the apoptotic pathway in a p53-independent...

Keywords:	CAY10572, 1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one, monohydrochloride
Application:	Cdc7 kinase inhibitor
CAS	942425-68-5
MW:	249.7 D

From 66.00€ *

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