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RG-7112
Item number: Cay25673-1
RG-7112 is an inhibitor of mouse double-minute 2 protein (MDM2, IC50 = 0.018 µM), an E3 ubiquitin ligase that ubiquitinates the tumor suppressor p53 and also acts as a negative regulator of p53 transcriptional activity. RG-7112 binds to the p53 binding pocket of MDM2. It increases the levels of p53 and its...
| Keywords: | RO5045337,... |
| Application: | MDM2 inhibitor |
| CAS | 939981-39-2 |
| MW: | 727.8 D |
From 85.00€
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RG7112
Item number: TGM-T6965-100mg
Description: RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor. Target: Mdm2, E1/E2/E3 Enzyme. Smiles: CCOc1cc(ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1)c1ccc(Cl)cc1)C(C)(C)C. References: Vu, Binh, Wovkulich, Peter, Pizzolato, Giacomo et al. Discovery of...
| Keywords: | RG-7112, RO5045337, RG 7112 |
| Application: | MDM2 inhibitor |
| CAS | 939981-39-2 |
| MW: | 727.78 D |
From 39.00€
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