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Item number: Cay16709-1

FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia. Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively). It also blocks the activities of the FLT3...

Keywords:	SB1518,...
Application:	FLT3 / JAK2 inhibitor
CAS	937272-79-2
MW:	472.6 D

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