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Tucatinib
Item number: Cay31411-5
Tucatinib is an inhibitor of HER2 (IC50 = 14 nM). It inhibits the phosphorylation of HER2 in BT474 breast carcinoma cells (IC50 = 21 nM). Tucatinib inhibits phosphorylation of AKT and induces apoptosis in BT474 cells. In vivo, tucatinib (25-100 mg/kg) inhibits tumor growth in NCI N87 gastric carcinoma and SKOV3...
| Keywords: | ARRY-380, ONT-380,... |
| Application: | HER2 inhibitor |
| CAS | 937263-43-9 |
| MW: | 480.5 D |
From 105.00€
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Tucatinib
Item number: TGM-T2364-100mg
Description: Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM). Target: EGFR, HER. Smiles: Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1. References: P Lee, et al. Cancer Research(Poster Session Abstracts). 2009, 69(24 Suppl):Abstract nr 5104.
| Keywords: | ARRY-380, Irbinitinib, ONT-380 |
| CAS | 937263-43-9 |
| MW: | 480.52 D |
From 30.00€
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