Description: R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 µM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils. Target: Others. Smiles:...

Diacylglycerol (DAG) kinases (DGKs) phosphorylate DAG to give phosphatidic acid (PA), reducing signaling through DAG and increasing signaling through PA. R-59-022 is an inhibitor of DGK (IC50 = 2.8 µM). This results in increased DAG-dependent PKC activity and potentiates aggregation of thrombin-stimulated platelets....