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AF-353 (hydrochloride)
Item number: Cay23034-5
AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells...
| Keywords: | Ro-4, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine |
| Application: | P2X3 receptor antagonist |
| CAS | 927887-18-1 |
| MW: | 436.7 D |
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AF-353 hydrochloride
Item number: TGM-T85192-10mg
Description: This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and...
| Keywords: | P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353 |
| Application: | P2X3 receptor antagonist |
| CAS | 927887-18-1 |
| MW: | 436.68 D |
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