Description: Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor. Target: DUB. Smiles: CCO\N=C1/c2ccccc2-c2nc(C#N)c(nc12)C#N. References: Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of...

DUBs-IN-2 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 280 nM). It is selective for USP8 over USP7 (IC50 = >100 µM). DUBs-IN-2 increases the level of programmed cell death protein ligand 1 (PD-L1) in H460 cells when used at a concentration of 2 µM and PC-9 cells at 2 and 4 µM. Intraperitoneal...