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ABT-263
Item number: LKT-A0777.5
ABT-263 is a BH3 mimetic that inhibits Bcl-2 and Bcl-xl. ABT-263's inhibition of Bcl-xl results in thrombocytopenia, limiting its usage. ABT-263 exhibits anticancer chemotherapeutic activity and shows some benefit in clinical trials. In chronic lymphocytic leukemia (CLL) cells, ABT-263 inhibits cell proliferation....
| Keywords: | Navitoclax, A-855071 |
| Application: | BH3 mimetic, Bcl-2 / Bcl-xl inhibitor |
| CAS | 923564-51-6 |
| MW: | 974.61 D |
From 108.00€
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ABT-263
Item number: Cay11500-5
ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = is = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment...
| Keywords: | A-855071, Navitoclax,... |
| Application: | Potent, cell-permeable BH3 domain mimetic |
| CAS | 923564-51-6 |
| MW: | 974.6 D |
From 33.00€
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