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Item number: LKT-R1217.1

RDEA119 inhibits MEK1/2 and exhibits anticancer chemotherapeutic activity. RDEA119 is currently in clinical trials as a potential treatment for a variety of advanced cancers. This compound inhibits proliferation in thyroid cancer cells, including those containing V600E B-Raf mutations. RDEA119 also inhibits tumor...

Keywords:	Refametinib, BAY 869766
Application:	MEK1/2 inhibitor
CAS	923032-37-5
MW:	572.34 D

From 156.00€ *

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Refametinib

Item number: Cay16997-1

Refametinib is an allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively). It blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM), inhibiting cell cycling in cancer cells but not in primary...

Keywords:	RDEA119, BAY 86-9766,...
Application:	MEK1/2 inhibitor
CAS	923032-37-5
MW:	572.3 D

From 52.00€ *

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