3 products were found matching "923032-37-5"!
No results were found for the filter!
RDEA119
Item number: LKT-R1217.1
RDEA119 inhibits MEK1/2 and exhibits anticancer chemotherapeutic activity. RDEA119 is currently in clinical trials as a potential treatment for a variety of advanced cancers. This compound inhibits proliferation in thyroid cancer cells, including those containing V600E B-Raf mutations. RDEA119 also inhibits tumor...
| Keywords: | Refametinib, BAY 869766 |
| Application: | MEK1/2 inhibitor |
| CAS | 923032-37-5 |
| MW: | 572.34 D |
From 164.00€
*
Refametinib
Item number: Cay16997-1
Refametinib is an allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively). It blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM), inhibiting cell cycling in cancer cells but not in primary...
| Keywords: | RDEA119, BAY 86-9766,... |
| Application: | MEK1/2 inhibitor |
| CAS | 923032-37-5 |
| MW: | 572.3 D |
From 57.00€
*
Refametinib
Item number: TGM-T6636-100mg
Description: Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). Target: MEK. Smiles: S(NC1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1OC)(=O)(=O)C3(C[C@@H](CO)O)CC3. References: Liu D, et al, Int J Cancer, 2010, 127(12), 2965-2973.
| Keywords: | BAY 86-97661 , BAY 869766 , RDEA119 |
| Application: | MEK1/2 inhibitor |
| CAS | 923032-37-5 |
| MW: | 572.34 D |
From 30.00€
*
