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Item number: TGM-T3615-100mg

Description: Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, possessing potential antineoplastic activity. Under hypoxic conditions, typical of hypoxic tumors, the 2-nitroimidazole moiety is reduced, releasing the...

Keywords:	TH-302
Application:	Antineoplastic, Alkylating agent
CAS	918633-87-1
MW:	449.04 D

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TH-302

Item number: Cay22195-1

TH-302 is a hypoxia-activated prodrug and DNA alkylating agent with anticancer activity. It is selectively cytotoxic to H460 human non-small cell lung cancer (NSCLC) cells grown under hypoxic over normoxic conditions (IC50s = 0.019 and 5.1 µM, respectively). Under hypoxic conditions, TH-302 undergoes a one-electron...

Keywords:	Evofosfamide, N,N'-bis(2-bromoethyl)-phosphorodiamidic acid, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
Application:	Antineoplastic, alkylating agent, prodrug
CAS	918633-87-1
MW:	449 D

From 55.00€ *

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