4 products were found matching "918505-84-7"!
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PLX4720
Item number: Cay15142-1
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of...
| Keywords: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Application: | BRAFV600E inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.8 D |
From 60.00€
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PLX4720
Item number: LKT-P4492.25
PLX-4720 is a potent and selective inhibitor of b-Raf(V600E) and c-Raf-1(Y340D/Y431D)
| Keywords: | N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| Application: | B-Raf (V600E) / c-Raf (Y340D/Y431D) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
From 213.00€
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PLX4720
Item number: AG-CR1-3577-M005
Synthetic. Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
| Keywords: | N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| Application: | B-Raf (V600E) / c-Raf-1 (Y340D/Y341D) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413,8 D |
From 94.00€
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PLX4720, Free Base
Item number: LC-P-8900_100mg
Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor...
| Keywords: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Application: | B-Raf(V600E) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
From 88.00€
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