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Item number: Cay18495-1

Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered...

Keywords:	(2S)-N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide
Application:	OX1R / OX2R antagonist
CAS	916141-36-1
MW:	470.6 D

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TCS 1102

Item number: TGM-T2710-100mg

Description: TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). Target: OX Receptor. Smiles: Cn1c(SCC(=O)N2CCC[C@@H]2C(=O)Nc2ccccc2-c2ccccc2)nc2ccccc12

Keywords:	DORA-1
Application:	OX1R / OX2R antagonist
CAS	916141-36-1
MW:	470.59 D

From 33.00€ *

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