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Item number: TGM-T10691-100mg

Description: CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM. Target: GPR. Smiles: O=C1C2(C=3C(N1CC(O)=O)=CC=C(Cl)C3)C(=O)N(CC4=C(F)C=CC(Cl)=C4)C(=O)C2. References: Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists...

CAS	916047-16-0
MW:	451.23 D

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CAY10595

Item number: Cay10012553-1

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is...

Keywords:	5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid
Application:	CRTH2receptor antagonist, DP2 receptor antagonist
CAS	916047-16-0
MW:	451.2 D

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