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MF498
MF498

Item number: Cay15973-1

Prostaglandin E2 (PGE2, Cay-14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, inflammation, cancer, and atherosclerosis. MF498 is a selective EP4 receptor antagonist (Ki...
Keywords: N-[[[4-(5,9-diethoxy-6,8-dihydro-6-oxo-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy-benzeneac...
Application: EP4 receptor antagonist
CAS 915191-42-3
MW: 603.7 D
From 102.00€ *
Review
MF498
MF498

Item number: TGM-T16069-10mg

Description: MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM). Target: Others. Smiles: CCOc1c2C(=O)N(Cc2c(OCC)c2ncccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2OC)cc1C. References: Clark P, et al. MF498...
Application: EP4 receptor antagonist
CAS 915191-42-3
MW: 603.69 D
From 232.00€ *
Review