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Item number: Cay11505-5

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...

Keywords:	Veliparib, 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
Application:	PARP1 / PARP2 inhibitor
CAS	912445-05-7
MW:	317.2 D

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Veliparib dihydrochloride

Item number: TGM-T2105-100mg

Description: Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Target: PARP, Autophagy. Smiles: Cl.Cl.C[C@@]1(CCCN1)c1nc2c(cccc2[nH]1)C(N)=O. References: Donawho CK, et al. ABT-888, an...

Keywords:	ABT-888 dihydrochloride
CAS	912445-05-7
MW:	317.21 D

From 30.00€ *

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