PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04928473 (SNX-2112, Cay-22359), which binds both Hsp90alpha and Hsp90beta with an IC50 value of 30 nM. The prodrug, PF-04929113, is rapidly absorbed and converted into the active inhibitor after oral administration. The active inhibitor causes degradation of Hsp90...

Description: PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF04929113 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers. Target: HSP, HER. Smiles:...