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Item number: Cay28447-10

SCH 546738 is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3, Ki = 0. nM). It is selective for CXCR3 over a panel of 49 other receptors at 10 µM. SCH 546738 (10 or 100 nM) inhibits chemotaxis induced by CXC ligand 9 (CXCL9), CXCL10, or CXCL11 in hemagglutinin- and IL-2-activated primary human T cells. It...

Keywords:	3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-2-pyrazinecarboxamide
Application:	CXCR3 antagonist
CAS	906805-42-3
MW:	492.44 D

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