A Bax activator (Ki = 43.3 nM in a fluorescence polarization assay), selectively reduces viability in wild-type but not Bax-/- MEFs at 25 µM, inhibits nicotine-induced increases in phosphorylated Bax levels in A549 cells at 5 µM, reduces viability in A549 cells at 5 µM, induces cell cycle arrest at the G2/M phase in...

Description: SMBA1 is a Bax activator and a potent Bax agonist (Ki : 43.3 nM) that induces cell cycle arrest and apoptosis in malignant glioma cells.SMBA1 has shown antitumor activity by enhancing Bax expression.SMBA1 can be used in cancer research. Target: Others. Smiles:...