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Item number: TGM-T6117-100mg

Description: Tivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. Target: c-Met/HGFR, Apoptosis. Smiles: O=C1NC(=O)[C@H]([C@@H]1c1c[nH]c2ccccc12)c1cn2CCCc3cccc1c23. References: Munshi N, et al. Mol Cancer Ther. 2010, 9(6), 1544-1553.

Keywords:	ARQ 197
Application:	Targets proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] (MET, HGFR)
CAS	905854-02-6
MW:	369.42 D

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Tivantinib

Item number: Cay17135-1

Tivantinib is an inhibitor of c-Met (Ki = 0.355 µM). It is selective for c-Met over a panel of 229 additional kinases at 10 µM. Tivantinib also inhibits tubulin polymerization in a cell-free assay in a concentration-dependent manner. It is cytotoxic to c-Met-dependent and -independent cancer cell lines when used at...

Keywords:	ARQ 197, (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione
Application:	Dephosphorylated c-Met kinase binding staurosporine derivative
CAS	905854-02-6
MW:	369.4 D

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