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Item number: TGM-T24136-100mg

Description: Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 µM, respectively. Target: E1/E2/E3 Enzyme. Smiles: CCc1ccc(\C=C\C(=O)Nc2ccc(cc2)C(C)=O)o1. References: Farris TR, et al. Ehrlichia chaffeensis TRP32 Nucleomodulin...

CAS	890605-54-6
MW:	283.32 D

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Heclin

Item number: Cay26139-1

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 µM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively). It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 µM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing...

Keywords:	N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Application:	HECT-type E3 ubiquitin ligase inhibitor
CAS	890605-54-6
MW:	283.3 D

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