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Item number: SYN-1225-M100

BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase...

Keywords:	BBT-594
Application:	Potent, selective RET / JAK2 inhibitor
CAS	890129-26-7
MW:	569.6 D

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BGG463

Item number: SYN-1226-M001

BGG463 (NVP-BGG463) was generated by a rational 'hybrid design' approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive 'DFG-out' conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL...

Keywords:	BGG-463
Application:	Kinase active state disruptor
CAS	890129-26-7
MW:	578.6 D

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