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MK-8745
Item number: Cay26190-5
MK-8745 is an Aurora A kinase inhibitor (IC50 = 0.6 nM) that is selective for Aurora A over Aurora B kinase (IC50 = 280 nM). It induces cell cycle arrest at the G2/M phase in non-Hodgkin lymphoma cells when used at a concentration of 1 µM. MK-8745 (5 µM) induces apoptosis and polyploidy in p53-positive and -negative...
| Keywords: | (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone |
| Application: | Aurora A kinase inhibitor |
| CAS | 885325-71-3 |
| MW: | 431.9 D |
From 67.00€
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MK-8745
Item number: TGM-T2471-10mg
Description: MK-8745 is a potent and selective Aurora A inhibitor. Target: Apoptosis, Aurora Kinase. Smiles: Fc1c(Cl)cccc1C(=O)N1CCN(Cc2cccc(Nc3nccs3)n2)CC1. References: Chowdhury A, et al. Leuk Lymphoma. 2012, 53(3), 462-471.
| Application: | Aurora A kinase inhibitor |
| CAS | 885325-71-3 |
| MW: | 431.91 D |
From 34.00€
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