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Item number: Cay10735-1

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not...

Keywords:	4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone
CAS	880487-62-7
MW:	317.4 D

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Phthalazinone pyrazole

Item number: TGM-T21981-100mg

Description: Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. Target: Apoptosis, Aurora Kinase. Smiles: Cc1cc(Nc2nn(-c3ccccc3)c(=O)c3ccccc23)n[nH]1

CAS	880487-62-7
MW:	317.34 D

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